Semaglutide, sold under brand names like Wegovy and Ozempic, is a medication originally developed to treat type 2 diabetes. Recently, it has gained popularity for its effectiveness in supporting significant weight loss. Understanding the semaglutide weight loss dosage chart is essential if you’re starting treatment or considering it. This article explains how the dosing works, what to expect at each stage, and how to stay safe during your journey.

What Is Semaglutide?

Semaglutide is a GLP-1 receptor agonist that mimics a hormone that helps regulate blood sugar, reduce appetite, and slow digestion. This combination of effects helps people feel full longer, eat less, and lose weight. Semaglutide for weight loss is available under the name Wegovy and is administered as a once-weekly injection. Many people also explore glp-1 supplements as an alternative or supportive option, especially when looking for non-prescription ways to achieve similar appetite-control effects.

If you’re looking to compare similar medications, this Mayo Clinic GLP-1 weight loss treatment comparison guide provides a helpful breakdown.

How Does Semaglutide Help with Weight Loss?

• Reduces hunger by acting on brain receptors that regulate appetite
• Slows gastric emptying, making you feel full longer
• Supports gradual, sustainable weight loss when combined with a low-calorie diet and physical activity

Semaglutide Weight Loss Dosage Chart (Wegovy)

The dosing schedule for semaglutide is carefully designed to help your body adjust to the medication and minimize side effects like nausea and upset stomach. Below is the standard dosage escalation chart for Wegovy:

Week(s)	Dose (mg) per week	Notes
Week 1–4	0.25 mg	Starting dose to help body adjust
Week 5–8	0.5 mg	Gradual increase, monitor side effects
Week 9–12	1.0 mg	Effects on appetite usually become clearer
Week 13–16	1.7 mg	Further appetite reduction
Week 17 onward	2.4 mg	Maintenance dose for long-term treatment

Note: Some individuals may stay longer at a lower dose if there are side effects. Always follow your healthcare provider’s instructions.

Key Tips While Using Semaglutide for Weight Loss

• Stick to the weekly injection schedule – Try to inject on the same day each week
• Watch for side effects – Common ones include nausea, vomiting, diarrhea, and constipation
• Eat slowly and in smaller portions – This helps avoid discomfort from slower digestion
• Stay hydrated – Especially important if you experience gastrointestinal symptoms
• Pair it with lifestyle changes – The best results come from combining semaglutide with healthy eating and activity

Who Should Use Semaglutide for Weight Loss?

Wegovy is FDA-approved for adults with:

• A BMI of 30 or higher (obesity)
• A BMI of 27 or higher (overweight) with at least one weight-related condition (e.g., hypertension, type 2 diabetes)

When to Contact Your Doctor

Reach out to your healthcare provider if you experience:

• Severe nausea or vomiting
• Signs of low blood sugar (especially if also taking diabetes medication)
• Any symptoms of allergic reaction or persistent abdominal pain

Is the Weight Loss Permanent?

Semaglutide helps support weight loss while you’re using the medication. However, if you stop using it and do not continue with lifestyle changes, weight regain is common. Long-term success depends on building and maintaining healthy habits.

To support your goals beyond semaglutide, read our guide on healthy fast food options to stay on track with better eating habits, even on busy days.

Conclusion

The semaglutide weight loss dosage chart provides a clear roadmap for how the medication is typically administered, starting from a low dose and increasing to the full maintenance dose over a few months. By following this plan under medical guidance, many experience meaningful and sustainable weight loss. Always consult your healthcare provider before starting semaglutide or making any changes to your dosage.

FAQs

How long does it take to see results with semaglutide?

Most people start seeing weight loss results within the first 8 to 12 weeks. However, individual responses vary based on lifestyle, metabolism, and dosage.

Can I stay on a lower dose if I can’t tolerate the higher ones?

Some individuals may remain at a lower dose if side effects are significant. Your healthcare provider will help determine the safest and most effective plan.

Do I need to change my diet while taking semaglutide?

While semaglutide reduces appetite, it works best with a healthy diet and physical activity. Reducing high-calorie and processed foods enhances results.

What should I do if I miss a dose?

If you miss a dose and it’s within 5 days, take it as soon as possible. If more than 5 days have passed, skip the missed dose and take the next dose on your scheduled day.

Is semaglutide suitable for people without diabetes?

Yes. Wegovy, the version of semaglutide approved for weight loss, is intended for people with obesity or overweight, regardless of whether they have diabetes.

Resources

• CDC – Adult BMI Calculator – Tool to calculate your BMI. Use here
• Mayo Clinic – Semaglutide for Weight Loss – Overview of benefits and risks. Learn more
• Harvard Health – Semaglutide for Obesity – Insights into effectiveness and side effects. Explore article